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. Author manuscript; available in PMC: 2023 May 23.
Published in final edited form as: Am J Med Genet A. 2023 Feb 24;191(5):1282–1292. doi: 10.1002/ajmg.a.63150

FIGURE 5.

FIGURE 5

Internal structures. Comparison of skull bases of Proband 3 (a) and Proband 4 (b). Proband 3 (a) with absent sella turcica. Arrow indicates fused optic nerve. No pituitary was present, even on subserial sectioning of the sphenoid. Proband 4 (b) demonstrates wide, shallow sella anterior to (arrow) fused optic nerve. A small pituitary was present. In both fetuses, the hypothalamus was disorganized and no infundibulum was present. Retroperitoneum demonstrating small adrenal glands (arrows) in Proband 3 (c) and Proband 4 (d).