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. 2023 May 9;14:1114424. doi: 10.3389/fendo.2023.1114424

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Copyright © 2023 Wu, Yang, Fan, Wei and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential therapy and treatments for T2DM by regulating gut microbiota and its metabolites. Recent approaches to regulate gut microbiota for T2DM therapy focuses on probiotics, prebiotics, synbiotics, fecal microbial transplantation, diet intervention, bacteriophages, microbiota-targeted drugs and postbiotics. SCFAs, short-chain fatty acids; FMT, Fecal Microbiota Transplantation; BAs,bile acids; LPS, Lipopolysaccharide; IL-10, Interleukin-10; GLP-1, glucagon-like peptide-1; ZO-1, zonula occludens-1.