A and B, rotarod and corner tests conducted within 21 days of stroke onset. The pretest was conducted one day before stroke onset, n=10 or 11. C and D, Open field test on days 14 and 21, and Novel object recognition test on day 21, n=7 in WT and n=6 in KO. A, [F(1, 78) = 18.64, P < 0.01], B, [F(1, 78) = 12.40, P< 0.01], C, [F(1, 22)= 28.76, P < 0.01], D, (P= 0.007), * or # P<0.05 compared with WT stroke; data are presented as the mean±SEM.