Table 2.
Pattern of biomarkers based on IHC
| Characteristic | Variable completeness (%) | Categories | Number (% of sample data)# |
|---|---|---|---|
| ER | 97.1 | Negative | 500 (51.6) |
| Positive | 469 (48.4) | ||
| -out of which - Staining intensity: | 293 (30.2) | ||
| 1+ (1%–9%) | |||
| 2+ (10%–33%) | 66 (6.8) | ||
| 3+ (>33%) | 110 (11.4) | ||
| PR | 97.0 | Negative | 554 (57.2) |
| Positive | 414 (42.8) | ||
| -out of which - Staining intensity: | 267 (27.6) | ||
| 1+ (1%–9%) | |||
| 2+ (10%–33%) | 71 (7.3) | ||
| 3+ (>33%) | 76 (7.9) | ||
| HER2/neu | 92.8 | Equivocal (2+) | 42 (4.5) |
| Negative (0 and 1+) | 704 (76.0) | ||
| Positive (3+) | 180 (19.4) | ||
| Ki-67 (n = 89) | 100 | Equivocal | 13 (14.6) |
| Negative | 15 (16.9) | ||
| Positive: out of which | 61 (68.5) | ||
| Staining intensity: Low (≤14%) | 46 (51.7) | ||
| Intermediate (15%–30%) | 9 (10.1) | ||
| High (>30%) | 6 (6.7) | ||
| Molecular | 98.4 | Lumina A (ER &/or PR+, HER2–) | 364 (37.1) |
| subtypes | Lumina B (ER &/or PR+, HER2+) | 86 (8.8) | |
| Triple negative (ER/PR–, HER2–) | 334 (34.0) | ||
| HER2-enriched (ER/PR-, HER2-) | 91 (9.3) | ||
| Inconclusive (ER/PR+, HER2?; ER/PR?, HER2+/–) | 107 (10.9) |
#Apart from Ki-67, for which the subgroup percentages are with respect to n = 89