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. 2023 May 23;18(5):e0285450. doi: 10.1371/journal.pone.0285450

Table 5. Absolute difference in cross-sectional area (CSA) measurements (mm2) between tunnel nerves and those proximal to the tunnel points on the same side by high-resolution ultrasonography in healthy volunteers and leprosy household contacts.

Nerves Healthy volunteers Seropositive HC Seronegative HC p1 value p2 value p3 value
Median (ΔMtpt) n 106 90 57
Mean ± SD 1.71 ± 1.25 1.61 ± 1.04 1.40 ± 0.82 >0.9999 >0.9999 >0.9999
Median (Q1/Q3) 1 (1/2) 2 (1/2) 2 (1/2)
95% CI [1.47–1.95] [1.4–1.85] [1.25–1.66]
Abnormal (>5.46) 0 0 0
Ulnar (ΔUtpt) n 106 98 60
Mean ± SD 1.09 ± 0.88 1.07 ± 0.91 0.98 ± 0.72 >0.9999 >0.9999 0.7345
Median (Q1/Q3) 1 (0/2) 1 (0/2) 1 (0,25/1)
95% CI [0.93–1.26] [0.89–1.25] [0.79–1.17]
Abnormal (>3.73) 0 1 (1.0%) 0
Tibial (ΔTtpt) n 106 98 60
Mean ± SD 0.8 ± 0.60 0.60 ± 0.71 0.47 ± 0.60 >0.9999 0.8095 0.8005
Median (Q1/Q3) 1 (0/1) 0 (0/1) 0 (0/1)
95% CI [0.47–0.7] [0.46–0.76] [0.31–0.62]
Abnormal (>2.38) 0 0 0

HC = household contacts; n = number of nerves; SD = standard deviation; Q1 = 25th percentile; Q3 = 75th percentile; 95% CI– 95% confidence interval; p1 value = healthy volunteers vs. seropositive HC; p2 value = healthy volunteers vs. seronegative HC; p3 value = seropositive HC vs. seronegative HC.

*Statistically significant.