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. Author manuscript; available in PMC: 2023 May 23.
Published in final edited form as: Virology. 2018 Oct 1;525:143–149. doi: 10.1016/j.virol.2018.09.009

Fig. 1. In vitro efficacy of three antiviral compounds.

Fig. 1.

(A) Chemical structures of LJ001, JL122, and JL118 (Vigant et al., 2013). (B) Concentrations up to 1 μM of each compound (LJ001, JL122 and JL118) were pre-incubated with 1×104 PFU/mL IHNV, VHSV or SVCV for 30 min while exposed to light. Viral titer was determined by plaque assay. Antiviral inhibition was compared between compounds. For all three viruses, JL122 completely blocked infection at 1.0 μM concentrations. JL122 was the most efficacious antiviral, followed by LJ001, and JL118 was least effective. Positive controls (PC) were virus pre-incubated with 0.01% DMSO (vehicle control). Data represents mean viral titer ± SE (n=3; experiments repeated 3 times). *: P<0.05, **: P<0.01, ***: P<0.001, ****: P<0.0001, ANOVA, Bonferroni’s Multiple Comparison Test.