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Synthesis of compounds D5 and D12. Reagents and conditions: (a) For 37a: (i) 2-phenylpropanoic acid (38), (COCl)2, DCM, cat. DMF, 0 °C to rt, 2 h; (ii) triphenyl phosphite (TPP), Py, 0 °C–70 °C, 2 h; iii) isobutylamine (40), 70 °C, overnight, 40%; (b) For 37b: (i) phenylacetyl chloride (39), TPP, Py, 0 °C–70 °C, 2 h; (ii) isobutylamine (40), 70 °C, overnight, 45%; (c) BBr3/DCM, DCM, −10 °C, 24 h, 50%–60%.
