Fig. 3.

Conformational variation pattern analysis in RBD and ACE2 binding of spike protein: (A) UMAP projection of the structural variation induced by the mutation pattern in each binding pattern. Patterns 1, 2, 3, and 4 are indicated in red, orange, yellow-green, and blue circles, respectively. (B–E) Counts of conformationally variable amino acids in the RBD in BA.1, 2, 2.75, and 5 variants. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)