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. 2023 May 15;33:101688. doi: 10.1016/j.tranon.2023.101688

Fig. 1.

Fig 1

Release of ctDNA from tumor cells occurs upon cell death as well as being secreted from tumor cells. ctDNA that enters CSF can then be collected from a ventricular access device or at lumbar puncture. Following DNA extraction, and further processing, specific mutations can be detected using non-NGS approaches or broader mutational profiles using NGS assays. Created with BioRender.com.