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. 2023 May 10;20:100657. doi: 10.1016/j.mtbio.2023.100657

Table 2.

Properties of photoresponsive hydrogels with different response mechanisms.

Article Information Composition of hydrogels Mechanisms of photoreactions Applications Advantages disadvantages
Wang et al.(2019)[27] Azobenzene、α-CD Photoisomerization Optoelectronic devices 1.Reversible
2.High biocompatibility
3.Rapid response
1.Additional light source required
2.Insufficient accuracy
Bian et al.(2017)[125] Azo-PDMAEMA
PAA、 β-CD
Photoisomerization Delivery applications
Satoh et al.(2011)[126] Sp、NIPAAm Photoisomerization Biomedical field
Delivery applications
1.Reversible
2.High biocompatibility
3.Suitable for use in the biomedical field
1.Slow response
Chen et al.(2017)[127] SP、Dox
N-bis(acryloyl)cystamine
Photoisomerization Cell imaging
Cai et al.(2019)[38] HA、O-nitrobenzyl alcohol Photo(de)crosslinking Cell culture 1.Reversible
2.Fast crosslinking
1.Durability decreases with time and repeated application
2. Requires photosensitizer
Lunzer et al.(2018)[128] O-nitrobenzyl、PEG、HA Photo(de)crosslinking Cell culture
Yang et al.(2017)[129] AzoAAM、β-CD Photo(de)crosslinking Sensors 1.Reversible
2.Self-healing
Cao et al.(2022)[130] Fe3O4、P(NIPAM-AM) Photothermal Actuators
Biomedical devices
1.Large bending angle(107.8°)
2.Reversible
3.Magnetic response
1.Prone to aggregation, reducing photothermal conversion efficiency
Lee et al.(2015)[124] MNP、PNIPAM Photothermal Actuators 1.Rapid response
2.Reversible
3.Constant curvature variation (k ​~ ​7.5 ​mm−1)
Shao et al.(2018)[131] BP、PDLLA-PEG-PDLLA Photothermal Photothermal therapy (PTT) 1. High biocompatibility and biodegradability
2. Suitable for biomedical applications
3. High photothermal antibacterial properties (>99.5% killing efficiency)
1.Urface modification is required to improve its stability