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. 2023 Apr 6;22(5):100544. doi: 10.1016/j.mcpro.2023.100544

Fig. 6.

Fig. 6

Phosphorylation events regulating synaptic processes in the stimulated neurointermediate lobe.A, SynGO cellular component (cc) enrichment analysis of all the proteins undergoing phosphorylation events in response to water deprivation (WD) in the NIL. B, SynGO biological processes (bp) enrichment analysis of all the proteins undergoing phosphorylation events in response to WD in the NIL. C, mapping the phosphosites and hyper and hypophosphorylation events in response to WD in proteins involved in the synaptic vesicle cycle. Protein domains include C2: Ca2+-dependent C2 domain; G: Pro-rich linker GTPase domain, GTPase domain; JMD: juxta-membrane domain; P-rich NT: proline-rich N-terminal domain; PDZ: post synaptic density domain; Rho GDI: RHO protein GDP dissociation inhibitor; RRM: RRM domain; SAC: SacI homology domain; Syn A, B, C, D, E, F, G, H, J: Synapsin domain A, B, C, D, E, F, G, H, J; SYT1 int: interaction with SYT1 domain; TMD: transmembrane domain; Z: Piccolo Zn-finger. D, mapping the phosphosites and hyper and hypophosphorylation events in response to WD in proteins involved in the presynaptic dense core vesicle exocytosis. C2, Ca2+-dependent C2 domain; DBD, dynactin 1 binding domain, DCV, dense core vesicle association domain, GED, Dynamin GTPase effector domain, GTPase, GTPase domain; MHD, Munc13-homology domain; NIL, neurointermediate lobe; PH, Pleckstrin homology domain.