Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters of pazopanib in rats.
| Rt01 | Rt02 | Rt03 | Rt04 | Rt05 | Average | SD | |
|---|---|---|---|---|---|---|---|
| Peak concentration (Cmax,obs, μM) | 73.3 | 60.0 | 69.2 | 50.4 | 60.0 | 62.6 | 8.0 |
| Time to maximum concentration (tmax,obs, h) | 8 | 4 | 3 | 8 | 5 | 5.6 | 2.1 |
| Area under the curve (AUC8h, μM·h) | 469.4 | 311.4 | 345.2 | 210.9 | 375.2 | 342.4 | 84.2 |
Cmax,obs: maximal drug concentration among the blood-sampling time points.
tmax,obs: time to Cmax,obs at blood-sampling points.
AUC8h: area under the curve from zero to 8 h.
