Figure 1.

Aortic technetium-99m (^99mTc)–tilmanocept single photon emission computed tomography (SPECT/CT) imaging among participants with or without human immunodeficiency virus (HIV). A, Aortic^99mTc-tilmanocept SPECT/CT. Representative axial SPECT/CT cuts from a participant with HIV (left) and a participant without HIV (right). Higher signal-to-background ratio (ie, ^99mTc-tilmanocept uptake signal-to-background ratio [SBR]) is depicted by red-orange on SPECT/CT images whereas a lower SBR is depicted by blue-purple on SPECT/CT images. The SPECT/CT image from the participant with HIV demonstrates a higher level of aortic ^99mTc-tilmanocept uptake. B, Aortic^99mTc-tilmanocept uptake on SPECT/CT. The percentage of aortic volume with ^99mTc-tilmanocept on SPECT/CT is demonstrated across different thresholds (3–6 times) at or above muscle activity. Each line (red for participants with HIV and blue for participants without HIV) connects the data for a single participant. Participants with HIV had a significantly higher percentage aortic volume with ^99mTc-tilmanocept uptake across different thresholds above muscle activity compared to participants without HIV (P = .02).