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. 2023 May 23;13:8319. doi: 10.1038/s41598-023-34730-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of virus interactomes in health and asthma. (a) Distribution (%) of the total number of virus interactions observed in health and/or in asthma. (b) Comparison of the virus APSP scores in health and in asthma; the difference between groups means is depicted (n = 30 viruses). (c) Comparison of the commonly observed virus and bacteria (n = 77) APSP scores in health and in asthma; the difference between groups means is depicted. Heatmaps of (d) the total virus interactions, and (e) the total eukaryotic virus interactions of each bacterial family (n = 63 and n = 60 families, respectively) within the virus interactomes in health and asthma. (f) Comparison of the mean APSP score of the eukaryotic virus-bacteria interactions (edges) for each bacterial family (n = 60) in health versus in asthma; the difference between groups means is depicted. Two-way ANOVA significance tests: *p < 0.05, **p < 0.001, ***p < 0.0001, ****p < 0.00001.