Table 1.
Demographic and clinical characteristics of colorectal cancer cases according to PD-L1+ and PD-L1– macrophage densities.
| Characteristic | Total N | Overall cell density (cells/mm2) Median (25–75th percentiles) |
|||
|---|---|---|---|---|---|
| PD-L1+ macrophages | P | PD-L1− macrophages | P | ||
| All cases | 910 (100%) | 59 (16–170) | 560 (380–780) | ||
| Sex | 0.50 | 0.47 | |||
| Male | 464 (51%) | 60 (17–160) | 570 (390–790) | ||
| Female | 446 (49%) | 59 (15–190) | 560 (370–770) | ||
| Age (years) | 0.18 | 0.95 | |||
| <65 | 247 (27%) | 54 (15–160) | 580 (360–790) | ||
| 65–75 | 331 (36%) | 58 (15–150) | 560 (390–750) | ||
| >75 | 332 (36%) | 74 (18–230) | 550 (370–800) | ||
| Tumour location | 0.0012 | 0.19 | |||
| Proximal colon | 445 (49%) | 74 (20–220) | 580 (420–790) | ||
| Distal colon | 332 (36%) | 51 (12–140) | 530 (360–750) | ||
| Rectum | 133 (15%) | 38 (15–160) | 560 (360–750) | ||
| AJCC stage | <0.0001 | 0.0049 | |||
| I | 151 (17%) | 84 (19–210) | 500 (340–670) | ||
| II | 342 (38%) | 84 (26–210) | 540 (390–790) | ||
| III | 301 (33%) | 47 (11–130) | 590 (420–800) | ||
| IV | 116 (13%) | 26 (6.6–100) | 650 (370–890) | ||
| Tumour grade | <0.0001 | 0.73 | |||
| Low-grade (well to moderately differentiated) | 760 (84%) | 55 (15–160) | 560 (370–780) | ||
| High-grade (poorly differentiated) | 150 (16%) | 104 (24–310) | 570 (410–760) | ||
| Lymphovascular invasion | <0.0001 | 0.20 | |||
| No | 719 (79%) | 70 (21–190) | 550 (380–770) | ||
| Yes | 191 (21%) | 32 (6.5–100) | 600 (380–820) | ||
| MMR status | <0.0001 | 0.20 | |||
| MMR proficient | 772 (85%) | 48 (12–150) | 550 (370–780) | ||
| MMR deficient | 137 (15%) | 190 (60–350) | 590 (460–770) | ||
| BRAF status | <0.0001 | 0.046 | |||
| Wild-type | 763 (84%) | 52 (14–160) | 550 (370–770) | ||
| Mutant | 147 (16%) | 98 (37–290) | 590 (440–790) | ||
AJCC American Joint Committee on Cancer, MMR mismatch repair.