Table 3.
Extraction recovery of lenvatinib and the internal standard from plasma.
| Drugs | QC samples | Recovery (%) | |||
|---|---|---|---|---|---|
| Mice | Rats | Dogs | Monkeys | ||
| Lenvatinib | LQC | 77.1 ± 1.3 | 81.4 ± 2.2 | 77.8 ± 2.6 | 92.9 ± 9.3 |
| MQC | 83.3 ± 0.4 | 79.5 ± 0.4 | 84.5 ± 0.9 | 84.6 ± 1.2 | |
| HQC | 84.2 ± 1.2 | 82.4 ± 1.0 | 82.9 ± 1.5 | 84.7 ± 1.4 | |
| IS | 82.3 ± 1.1 | 79.4 ± 1.1 | 81.7 ± 1.0 | 88.4 ± 1.2 | |
HQC high QC, IS internal standard, LQC low QC, MQC mid QC, QC quality control.
Triplicates per concentration were assayed and mean ± standard deviation of extraction recovery was represented.