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. 2023 Apr 3;128(11):2013–2024. doi: 10.1038/s41416-023-02253-7

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Fig. 1 — a Whole-exome mutational analysis of parental and CDDP-resistant (R) clones. b Spectrum of KEAP1 mutations in CDDP-resistant clones. c KEAP1 mRNA is downregulated in all individual PCI13 CDDP-resistant clones. ***P < 0.001, **P < 0.01, *P < 0.05. d Venn diagram of genes upregulated by ≥1.5-fold in CDDP-resistant clones as determined by the Dunnett’s multiple comparison test (FDR < 0.1). Distribution of functional classes among genes upregulated (e) or downregulated (f) in at least two clones from at least two backgrounds. Essential, selective, and inert are defined in the text and observed distribution was compared to the expected distribution with a Chi-square test.