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. 2023 Apr 3;128(11):2013–2024. doi: 10.1038/s41416-023-02253-7

Fig. 6. Differential carbon flux in CDDP-resistant clones.

Fig. 6

a Under normal growth conditions, there is increased 13C incorporation from 15 mM all carbon 13C-labelled glucose (GLC) in CDDP-resistant clones into serine (Ser) (48 h). b Overall, 13C from GLC is incorporated to a greater degree in HN30R4E1 compared to HN30 as is 13C from Gln (c). m + x denotes 13C labelling of x carbon atoms. (*P < 0.05; **P < 0.01; ***P < 0.001). d Conceptual summary of increased biomass generation designed to absorb CDDP-generated stress in CDDP-resistant cells, preventing DNA binding and damage.