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. 2023 May 10;14:1177026. doi: 10.3389/fphar.2023.1177026

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Copyright © 2023 Chotiyanonta, Onda, Nowrangi, Li, Xu, Adams, Lyketsos, Zandi and Oishi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A, B) Bubble plots showing the relationships between CIBIC-plus and NOTE scores through drugs (A) SSRI psychiatric scores and (B) CEI cognitive scores). (C–E) Bubble plots showing the relationship between MMSE changes and cognitive NOTE scores by drugs: (C) SSRI + CEI, (D) SSRI, and (E) CEI. A solid blue line and a light blue area represent the regression line with its 95% confidence intervals. The mean coefficient, 95% confidence interval of Spearman’s rank correlation, and the legend of sample sizes (for C–E) are shown in the upper right corner of the graph. The mean coefficient and its confidence interval are estimated based on bootstrapping with 10,000 resampling iterations, using the bias-corrected and -accelerated method.