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. 2023 May 10;14:1177026. doi: 10.3389/fphar.2023.1177026

TABLE 1.

Keywords found within EMRs.

Implication Clinical note keywords
SSRI a SSRIs, citalopram, Celexa, escitalopram, Lexapro, fluoxetine, Prozac, Sarafem, Symbyax, fluvoxamine, Luvox, paroxetine, Paxil, Pexeva, sertraline, Zoloft, vilazodone, and Viibryd
CEI a Cholinesterase inhibitor, donepezil, Aricept, rivastigmine, Exelon, galantamine, Razadyne, and Namzaric
Cognitive assessments a MMSE, Mini-Mental State Exam and MoCA, Montreal Cognitive Assessment
Psychiatric note b Depression, depressed, anxious, anxiety, mood, ruminating thoughts, nighttime disruption, hallucination, focus, attention, concentration, alert, irritation, irritability, irritated, agitation, agitated, behavior, challenging behavior, panic attack, frustration, apathy, communicative, altered, confusion, mood swings, emotional, emotionally, tearful, crying, anger, positivity, sleep, sad, no energy, personality, paranoia, feeling, impulsivity, active, engaged, motivated, hopeful, interactive, interacting, verbal, aware, delusions, aggression, dysphoria, elation, euphoria, indifference, disinhibition, disinhibited, labile, lability, motor disturbances, nighttime behavior, psychiatric, and psychiatric symptoms
Cognitive note b Recall, memory, short-term memory, long-term memory, episodic memory, cognition, cognitive, cognitive performance, cognitive function, cognitive symptoms, dementia, Alzheimer’s, word finding difficulty, sharp, sharper, clarity, memory loss, memory lapses, remembering, repeating him/herself, repeating questions, repetitions, mentation
Improve c Improve, improvement, improved, improving, better, well, doing well, [medication] working well, help, helped, helpful, benefits, less/decreased/improvement in/reduction in [problematic symptoms], [psychiatric symptoms] stable/controlled/under control, remembering more things, no longer depressed, not depressed, does not feel depressed, sharper, more [positive behavior such as hopeful/active/engaging/interactive/verbal], close to normal, almost all the way back to baseline, calmed down, calmer, positive effect, and positive turn around
No change c No change, unchanged, no major/significant change, no benefit, uncertain benefit, no improvement, not noticed a/any difference, not made noticeable difference, [cognitive symptoms] stable/stabilized, about the same, same, not helpful, did not help, didn’t help, ineffective, lack of effect, no significant deterioration, no worsening of symptoms, continued [previously mentioned symptoms], remain, still have [symptoms], has not done much, and [cognitive symptoms] not progressing
Worsen c Worsen, worsened, worse, worst, worsening, more/increased/increasingly/worsening of/advancement in [psychiatric/cognitive symptoms], more trouble, continue to decline, and decline in memory/cognition/focus/concentration
Markedly d Markedly, marked, significant, significantly, much, very, very much, really, great, greatly, quite, dramatic, dramatically, clear, clearly, notable, notably, and noticeably
Moderately d Moderately and moderate
Slightly d Slightly, slight, minimally, minimal, bit, little, little bit, some, and somewhat
a

SSRIs, CEIs, and cognitive assessments: various prescription names and cognitive assessments searched within EMRs.

b

Psychiatric and cognitive notes: classified comments that were found within clinical notes.

c

Improve, no change, or worsen: clinical comments classified for a three-point scale of the NOTE score, which is as follows: 1 = improve, 2 = no change, and 3 = worsen.

d

Markedly, moderately, and slightly: clinical comments classified for a seven-point scale, which is as follows: 1 = markedly improved, 2 = moderately improved, 3 = slightly improved, 4 = unchanged, 5 = slightly worse, 6 = moderately worse, and 7 = markedly worse. Keywords for improved, unchanged, and worse are the same as the NOTE classification.