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. 2023 May 10;14:1177026. doi: 10.3389/fphar.2023.1177026

TABLE 3.

Proportion of age, sex, and diagnostic codes in relation to the results of NOTE.

Drug Variable Effectiveness of the NOTE score a Statistics b
Total N/A c Intolerance Improved No change Worsen p-value
SSRI Diagnosis code, n (%) 0.70
AD d 73 (100%) 3 (4.1%) 4 (5.5%) 50 (68%) 9 (12%) 7 (9.6%)
VD d 42 (100%) 1 (2.4%) 3 (7.1%) 27 (64%) 8 (19%) 3 (7.1%)
AD + VD 20 (100%) 1 (5.0%) 1 (5.0%) 16 (80%) 2 (10%) 0 (0%)
Others 90 (100%) 1 (1.1%) 9 (10%) 63 (70%) 9 (10%) 8 (8.9%)
Sex, n (%) 0.20
Woman 117 (100%) 4 (3.4%) 11 (9.4%) 80 (68%) 10 (8.5%) 12 (10%)
Man 108 (100%) 2 (1.9%) 6 (5.6%) 76 (70%) 18 (17%) 6 (5.6%)
Age at the start of the medication, mean (SD) 0.45
73 (9.7) 70 (10.4) 72 (12.7) 73 (9.2) 76 (8.6) 72 (12.4)
Total, n (%)
225 (100%) 6 (2.7%) 17 (7.6%) 156 (69%) 28 (12%) 18 (8.0%)
CEI Diagnosis code, n (%) 0.66
AD 54 (100%) 3 (5.6%) 2 (3.7%) 15 (28%) 19 (35%) 15 (28%)
VD 13 (100%) 1 (7.7%) 2 (15%) 3 (23%) 4 (31%) 3 (23%)
AD + VD 13 (100%) 0 (0%) 1 (7.7%) 6 (46%) 4 (31%) 2 (15%)
Others 35 (100%) 3 (8.6%) 7 (20%) 7 (20%) 13 (37%) 5 (14%)
Sex, n (%) 0.20
Woman 55 (100%) 6 (11%) 3 (5.5%) 13 (24%) 20 (36%) 13 (24%)
Man 60 (100%) 1 (1.7%) 9 (15%) 18 (30%) 20 (33%) 12 (20%)
Age at the start of the medication, mean (SD) 0.30
74 (8.8) 79 (7.7) 77 (10.1) 73 (9.7) 74 (8.5) 73 (7.6)
Total, n (%)
115 (100%) 7 (6.1%) 12 (10%) 31 (27%) 40 (35%) 25 (22%)
a

SSRI, psychiatric NOTE score; CEI, cognitive NOTE score.

b

Type II likelihood ratio test on the multinomial model.

c

N/A, prioritized comment on the treatment effect not available.

d

AD, Alzheimer’s disease; VD, vascular dementia.