TABLE 3.
Drug | Variable | Effectiveness of the NOTE score a | Statistics b | |||||
---|---|---|---|---|---|---|---|---|
Total | N/A c | Intolerance | Improved | No change | Worsen | p-value | ||
SSRI | Diagnosis code, n (%) | 0.70 | ||||||
AD d | 73 (100%) | 3 (4.1%) | 4 (5.5%) | 50 (68%) | 9 (12%) | 7 (9.6%) | ||
VD d | 42 (100%) | 1 (2.4%) | 3 (7.1%) | 27 (64%) | 8 (19%) | 3 (7.1%) | ||
AD + VD | 20 (100%) | 1 (5.0%) | 1 (5.0%) | 16 (80%) | 2 (10%) | 0 (0%) | ||
Others | 90 (100%) | 1 (1.1%) | 9 (10%) | 63 (70%) | 9 (10%) | 8 (8.9%) | ||
Sex, n (%) | 0.20 | |||||||
Woman | 117 (100%) | 4 (3.4%) | 11 (9.4%) | 80 (68%) | 10 (8.5%) | 12 (10%) | ||
Man | 108 (100%) | 2 (1.9%) | 6 (5.6%) | 76 (70%) | 18 (17%) | 6 (5.6%) | ||
Age at the start of the medication, mean (SD) | 0.45 | |||||||
73 (9.7) | 70 (10.4) | 72 (12.7) | 73 (9.2) | 76 (8.6) | 72 (12.4) | |||
Total, n (%) | ||||||||
225 (100%) | 6 (2.7%) | 17 (7.6%) | 156 (69%) | 28 (12%) | 18 (8.0%) | |||
CEI | Diagnosis code, n (%) | 0.66 | ||||||
AD | 54 (100%) | 3 (5.6%) | 2 (3.7%) | 15 (28%) | 19 (35%) | 15 (28%) | ||
VD | 13 (100%) | 1 (7.7%) | 2 (15%) | 3 (23%) | 4 (31%) | 3 (23%) | ||
AD + VD | 13 (100%) | 0 (0%) | 1 (7.7%) | 6 (46%) | 4 (31%) | 2 (15%) | ||
Others | 35 (100%) | 3 (8.6%) | 7 (20%) | 7 (20%) | 13 (37%) | 5 (14%) | ||
Sex, n (%) | 0.20 | |||||||
Woman | 55 (100%) | 6 (11%) | 3 (5.5%) | 13 (24%) | 20 (36%) | 13 (24%) | ||
Man | 60 (100%) | 1 (1.7%) | 9 (15%) | 18 (30%) | 20 (33%) | 12 (20%) | ||
Age at the start of the medication, mean (SD) | 0.30 | |||||||
74 (8.8) | 79 (7.7) | 77 (10.1) | 73 (9.7) | 74 (8.5) | 73 (7.6) | |||
Total, n (%) | ||||||||
115 (100%) | 7 (6.1%) | 12 (10%) | 31 (27%) | 40 (35%) | 25 (22%) |
SSRI, psychiatric NOTE score; CEI, cognitive NOTE score.
Type II likelihood ratio test on the multinomial model.
N/A, prioritized comment on the treatment effect not available.
AD, Alzheimer’s disease; VD, vascular dementia.