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. 2023 May 10;14:1137609. doi: 10.3389/fphar.2023.1137609

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Copyright © 2023 Xu, Chen, Yi, Tian, Liu, Ouyang, Yuan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BHD improves mitochondrial function in MCAO mice through Cav-1. (A) BHD improves CS activity in MCAO mice through Cav-1 (n = 6). (B) BHD improves NADH-coenzyme Q in MCAO mice through Cav-1 (n = 6). (C) BHD improves succinate-coenzyme Q in MCAO mice through Cav-1 (n = 6). (D) BHD improves coenzyme Q-cytochrome C in MCAO mice through Cav-1 (n = 6). (E) BHD improves cytochrome C oxidase in MCAO mice through Cav-1 (n = 6). (F) BHD improves ATP content in MCAO mice through Cav-1 (n = 6). (G,H) BHD improves ATPase activity in MCAO mice through Cav-1 (n = 6). All data are presented as the mean ± SD. **p < 0.01 vs. syngeneic sham group, ^## p < 0.01 vs. syngeneic model group, ^▲ p < 0.05 and ^▲▲ p < 0.01 vs. WT model group, ^◇ p < 0.05 and ^◇◇ p < 0.01 vs. WT BHD group.