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. 2023 May 10;14:1137609. doi: 10.3389/fphar.2023.1137609

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Copyright © 2023 Xu, Chen, Yi, Tian, Liu, Ouyang, Yuan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BHD promotes mitochondrial biogenesis in MCAO mice through Cav-1. (A–C) Western blot and quantitative analysis of SIRT1 and PGC-1α (n = 3). (D,E) RT‒qPCR and quantitative analysis of SIRT1 and PGC-1α (n = 6) (F) BHD promotes mtDNA replication in MCAO mice through Cav-1. All data are presented as the mean ± SD. **p < 0.01 vs. syngeneic sham group, ^# p < 0.05 and ^## p < 0.01 vs. syngeneic model group, ^▲ p < 0.05 and ^▲▲ p < 0.01 vs. WT model group, ^◇ p < 0.05 and ^◇◇ p < 0.01 vs. WT BHD group.