Table 1.
MR estimates for the association between gut microbiota and sepsis (p < 1 × 10−5).
| Level | Microbiota | SNPs | R2 (%) | Methods | Beta | OR (95% CI) | p value |
|---|---|---|---|---|---|---|---|
| Class | Deltaproteobacteria | 13 | 6.0 | Inverse variance weighted | −0.16 | 0.85 (0.74, 0.97) | 0.018 |
| MR Egger | −0.00 | 1.00 (0.68, 1.46) | 0.992 | ||||
| Simple mode | −0.26 | 0.77 (0.56, 1.06) | 0.139 | ||||
| Weighted median | −0.16 | 0.85 (0.70, 1.03) | 0.097 | ||||
| Weighted mode | −0.16 | 0.85 (0.65, 1.12) | 0.262 | ||||
| Order | Desulfovibrionales | 12 | 5.6 | Inverse variance weighted | −0.15 | 0.86 (0.75, 0.99) | 0.032 |
| MR Egger | −0.05 | 0.96 (0.66, 1.38) | 0.815 | ||||
| Simple mode | −0.24 | 0.79 (0.58, 1.09) | 0.174 | ||||
| Weighted median | −0.15 | 0.86 (0.71, 1.04) | 0.129 | ||||
| Weighted mode | −0.18 | 0.84 (0.65, 1.08) | 0.191 | ||||
| Family | Clostridiaceae1 | 10 | 4.5 | Inverse variance weighted | 0.21 | 1.24 (1.03, 1.48) | 0.023 |
| MR Egger | 0.22 | 1.25 (0.72, 2.17) | 0.448 | ||||
| Simple mode | 0.24 | 1.27 (0.87, 1.85) | 0.249 | ||||
| Weighted median | 0.20 | 1.22 (0.98, 1.54) | 0.079 | ||||
| Weighted mode | 0.21 | 1.24 (0.91, 1.68) | 0.210 | ||||
| Genus | Alloprevotella | 6 | 6.5 | Inverse variance weighted | 0.13 | 1.14 (1.03, 1.25) | 0.010 |
| MR Egger | −0.35 | 0.70 (0.28, 1.74) | 0.488 | ||||
| Simple mode | 0.13 | 1.14 (0.95, 1.37) | 0.211 | ||||
| Weighted median | 0.13 | 1.14 (1.01, 1.29) | 0.036 | ||||
| Weighted mode | 0.14 | 1.15 (0.96, 1.36) | 0.187 | ||||
| Catenibacterium | 5 | 5.2 | Inverse variance weighted | −0.13 | 0.88 (0.79, 0.98) | 0.018 | |
| MR Egger | 0.13 | 1.14 (0.40, 3.21) | 0.826 | ||||
| Simple mode | −0.18 | 0.84 (0.68, 1.04) | 0.182 | ||||
| Weighted median | −0.12 | 0.88 (0.76, 1.03) | 0.110 | ||||
| Weighted mode | −0.16 | 0.85 (0.68, 1.06) | 0.217 | ||||
| Hungatella | 5 | 4.2 | Inverse variance weighted | −0.18 | 0.84 (0.71, 0.98) | 0.026 | |
| MR Egger | −0.27 | 0.76 (0.24, 2.41) | 0.675 | ||||
| Simple mode | −0.19 | 0.82 (0.63, 1.08) | 0.227 | ||||
| Weighted median | −0.16 | 0.85 (0.71, 1.02) | 0.081 | ||||
| Weighted mode | −0.11 | 0.89 (0.69, 1.15) | 0.440 | ||||
| LachnospiraceaeND3007group | 3 | 2.4 | Inverse variance weighted | 0.33 | 1.39 (1.02, 1.89) | 0.038 | |
| MR Egger | −0.83 | 0.44 (0.00, 78.11) | 0.806 | ||||
| Simple mode | 0.23 | 1.26 (0.82, 1.93) | 0.399 | ||||
| Weighted median | 0.26 | 1.30 (0.89, 1.91) | 0.175 | ||||
| Weighted mode | 0.24 | 1.27 (0.81, 1.98) | 0.404 | ||||
| Terrisporobacter | 5 | 3.5 | Inverse variance weighted | 0.16 | 1.18 (1.02, 1.36) | 0.030 | |
| MR Egger | 0.27 | 1.31 (0.88, 1.95) | 0.280 | ||||
| Simple mode | 0.23 | 1.25 (0.97, 1.61) | 0.155 | ||||
| Weighted median | 0.20 | 1.22 (1.01, 1.47) | 0.034 | ||||
| Weighted mode | 0.22 | 1.24 (0.97, 1.59) | 0.163 |
SNPs, the number of SNPs being used as IVs; R2, the proportion of phenotypic variation explained by SNPs.