Table 2.

Evaluation of heterogeneity and directional pleiotropy using different methods.

Level	Microbiota	Heterogeneity	Horizontal pleiotropy
		Cochran’s Q p	MR-Egger intercept p	MR-PRESSO global test p
Class	Deltaproteobacteria	0.566	0.391	0.630
Order	Desulfovibrionales	0.708	0.555	0.758
Family	Clostridiaceae1	0.177	0.962	0.198
Genus	Alloprevotella	0.744	0.354	0.788
	Catenibacterium	0.437	0.661	0.480
	Hungatella	0.152	0.885	0.212
	LachnospiraceaeND3007group	0.694	0.737	/*
	Terrisporobacter	0.751	0.613	0.862

^*Not enough instrumental variables for MR-PRESSO analysis.