Table 3.

MR estimates for the association between gut microbiota and sepsis (p < 5 × 10⁻⁸).

Level	Microbiota	SNPs	Methods	Beta	SE	OR (95% CI)	p value
Total		14	Inverse variance weighted	<0.01	0.04	1.00 (0.92, 1.09)	0.950
			MR Egger	0.04	0.15	1.04 (0.78, 1.38)	0.815
			Simple mode	−0.05	0.09	0.95 (0.80, 1.13)	0.581
			Weighted median	−0.02	0.06	0.98 (0.88, 1.10)	0.730
			Weighted mode	−0.02	0.07	0.98 (0.84, 1.13)	0.758
Phylum	Actinobacteria	1	Wald ratio	−0.26	0.20	0.77 (0.52, 1.15)	0.205
Class	Actinobacteria	1	Wald ratio	−0.20	0.15	0.82 (0.61, 1.11)	0.205
Order	Bifidobacteriales	2	Inverse variance weighted	−0.13	0.13	0.88 (0.68, 1.14)	0.322
	Gastranaerophilales	1	Wald ratio	0.15	0.14	1.17 (0.88, 1.54)	0.282
Family	Bifidobacteriaceae	2	Inverse variance weighted	−0.13	0.13	0.88 (0.68, 1.14)	0.322
	Oxalobacteraceae	1	Wald ratio	−0.08	0.14	0.92 (0.71, 1.20)	0.552
	Peptostreptococcaceae	1	Wald ratio	−0.14	0.21	0.87 (0.58, 1.30)	0.499
	Streptococcaceae	1	Wald ratio	0.22	0.22	1.24 (0.80, 1.93)	0.329
	unknownfamily.id.1000001214	1	Wald ratio	0.15	0.14	1.17 (0.88, 1.54)	0.282
Genus	Allisonella	1	Wald ratio	−0.02	0.10	0.98 (0.81, 1.18)	0.835
	Bifidobacterium	2	Inverse variance weighted	−0.23	0.15	0.80 (0.59, 1.07)	0.135
	Enterorhabdus	1	Wald ratio	0.21	0.15	1.23 (0.92, 1.64)	0.165
	Erysipelatoclostridium	1	Wald ratio	−0.06	0.17	0.94 (0.68, 1.32)	0.740
	Eubacteriumcoprostanoligenesgroup	1	Wald ratio	−0.25	0.23	0.78 (0.50, 1.22)	0.276
	Oxalobacter	1	Wald ratio	0.07	0.12	1.07 (0.84, 1.37)	0.561
	Romboutsia	1	Wald ratio	−0.14	0.20	0.87 (0.58, 1.30)	0.499
	RuminococcaceaeUCG013	1	Wald ratio	−0.21	0.23	0.81 (0.52, 1.27)	0.357
	Ruminococcus1	1	Wald ratio	0.24	0.22	1.27 (0.82, 1.97)	0.281
	Streptococcus	1	Wald ratio	0.21	0.21	1.23 (0.81, 1.87)	0.329
	Tyzzerella3	1	Wald ratio	−0.02	0.12	0.98 (0.78, 1.24)	0.867
	unknowngenus.id.1000001215	1	Wald ratio	0.15	0.14	1.17 (0.88, 1.54)	0.282