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Schematic illustration of (A) the synthetic process for dual-crosslinked hydrogels (SP@PRP, SP@PRP, and SP@PRP) and their use as diabetic wound dressings; (B) Factor XIIIa catalyzes a chemical reaction resulting in insoluble fibrin highly covalently crosslinked through glutamine and lysine residues; (C) Ca+2-silk protein interactions in SP@PRP activated with calcium gluconate, and (D) formation of exosome-loaded genipin-crosslinked silk protein hydrogels.
