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. 2023 May 13;63:102745. doi: 10.1016/j.redox.2023.102745

Fig. 10.

Fig. 10

EX-527 reversed the protective effect of NMN against inflammaroty and oxidative responses to LPS in BV-2 cells. (A) Supernatant TNF-α. (B) Supernatant IL-6. (C) Supernatant IL-1β. (D) The SOD activity in BV-2. (E) MDA content in BV-2. (F, G) The level of ROS in BV-2 as detected by flow cytometry. (H–M) Expression and the relative quantification of SIRT1, PGC-1α, and acetylation level of lysine in BV-2. (N–P) Phosphorylation and the relative quantification of P38 and P65. Tukey post-hoc test following one-way ANOVA was used. The values were presented as mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001, n = 4 or 6 for each group).