Fig. 5.

NMN reduced the levels of inflammatory factors in the plasma and hippocampus, and attenuated the oxidative stress in hippocampus of septic mice at 24 h after surgery. (A) Plasma TNF-α. (B) Plasma IL-6. (C) Plasma IL-1β. (D) TNF-α in hippocampus. (E) IL-6 in hippocampus. (F) IL-1β in hippocampus. (G) The SOD activity. (H) MDA content. (I, J) Representative images and quantification of ROS immunostaining in the hippocampus region. Scale bar = 20 μm. Tukey post-hoc test following a two-way ANOVA was used. The values were presented as mean ± SD (**p < 0.01, ***p < 0.001, n = 6 for each group).