Table 3.
Follow-up characteristics.
| Parameter | All (n = 221) | Normal ePVS (n = 148) | High ePVS (n = 73) | p value |
|---|---|---|---|---|
| Age, years | 68 [55, 76] n = 221 |
66 [52, 75] n = 148 |
69 [58, 76] n = 73 |
0.187 |
| Female sex, n (%) | 130 (59%) n = 221 |
72 (49%) n = 148 |
58 (80%) n = 73 |
<0.001 |
| Diagnosis of IPAH, n (%) | 108 (49%) n = 221 |
80 (54%) n = 148 |
28 (38%) n = 73 |
0.040 |
| Edema, n (%) | 59 (27%) n = 154 |
39 (26%) n = 108 |
20 (27%) n = 46 |
0.462 |
| Diuretic treatment, n (%) | 134 (61%) n = 177 |
94 (64%) n = 125 |
40 (55%) n = 52 |
0.959 |
| Hemoglobin, g/dl | 13.5 [12.1, 14.8] n = 221 |
14.5 [13.5, 15.5] n = 148 |
11.5 [10.6, 12.0] n = 73 |
<0.001 |
| Hematocrit | 0.41 [0.38, 0.44] n = 221 |
0.43 [0.41, 0.46] n = 148 |
0.35 [0.33, 0.38] n = 73 |
<0.001 |
| Weight, kg | 76 [67, 85] n = 106 |
76 [68, 85] n = 79 |
75 [66, 82] n = 27 |
0.442 |
| Height, cm | 169 [163, 175] n = 201 |
170 [164, 178] n = 134 |
167 [160, 172] n = 67 |
0.003 |
| mPAP, mmHg | 42 [35, 51] n = 76 |
40 [34, 48] n = 47 |
43 [38, 54] n = 29 |
0.089 |
| PAWP, mmHg | 10 [6, 13] n = 76 |
8 [6, 12] n = 47 |
11 [9, 15] n = 29 |
0.015 |
| Pulmonary vascular resistance, dyn·s/cm5 | 561 [386, 679] n = 76 |
521 [385, 663] n = 47 |
611 [409, 686] n = 29 |
0.438 |
| CVP, mmHg | 7 [4, 10] n = 76 |
6 [4, 9] n = 47 |
9 [7, 12] n = 29 |
0.002 |
| Cardiac index, L/min/m2 | 2.48 [2.13, 2.98] n = 76 |
2.42 [2.12, 2.87] n = 47 |
2.56 [2.13, 3.06] n = 29 |
0.630 |
| Mixed venous oxygen saturation, % | 65 [59, 69] n = 76 |
66 [63, 70] n = 47 |
63 [56, 68] n = 29 |
0.008 |
| ePVS, ml/g | 4.37 [3.80, 5.16] n = 221 |
3.97 [3.44, 4.37] n = 148 |
5.58 [5.17, 6.42] n = 73 |
<0.001 |
| BNP, pg/ml | 114 [44, 259] n = 192 |
98 [32, 245] n = 129 |
147 [74, 329] n = 63 |
0.010 |
| eGFR, ml/min/1.73 m2 | 69 [50, 89] n = 106 |
75 [55, 94] n = 79 |
56 [44, 77] n = 27 |
<0.001 |
| TAPSE, mm | 20 ± 4 n = 199 |
20 ± 4 n = 133 |
20 ± 4 n = 66 |
0.183 |
| TAPSE/PASP, mm/mmHg | 0.340 [0.247, 0.500] n = 181 |
0.356 [0.263, 0.500] n = 120 |
0.310 [0.232, 0.510] n = 51 |
0.101 |
| Right atrial area, cm2 | 18 [15, 23] n = 194 |
18 [15, 23] n = 129 |
17 [14, 23] n = 65 |
0.458 |
| Inferior vena cava diameter, mm | 19 ± 5 n = 81 |
19 ± 6 n = 52 |
20 ± 5 n = 29 |
0.824 |
Data are presented as median [Q1, Q3] or mean ± standard deviation unless otherwise specified. BNP, brain natriuretic peptide; CVP, central venous pressure; eGFR, estimated glomerular filtration rate; ePVS, estimated plasma volume status; IPAH, idiopathic pulmonary arterial hypertension; mPAP, mean pulmonary arterial pressure; PASP, pulmonary arterial systolic pressure; PAWP, pulmonary arterial wedge pressure; TAPSE, tricuspid annular plane systolic excursion.