Table 7.
Peptide-nanoparticle conjugates enhance the efficiency of peptide-based theranostics
| Peptide | Nanoparticles | Target | Application | References |
|---|---|---|---|---|
|
TAT (GRKKRRQRRRPQ) |
Mesoporous Silica | Targets importin α and importin β | Nuclear target drug delivery | Zou et al. (2018) |
| Gold nanoparticle | Assists with membrane disruption and cellular uptake | Transdermal drug delivery | Niu et al. (2017) | |
| Nano lipid crystal nanoparticles | Binds to stratum corneum and assists movement of nanoparticles into epidermal layers | Transdermal drug delivery | Patlolla et al. (2010) | |
|
Adenoviral NLS (CGGFSTSLRARKA) |
Gold nanoparticles | Nuclear pore complex for nuclear uptake | Nuclear target drug delivery | Li et al., (2017) |
| BSA (Bovine Serum Albumin)-coated gold nanoparticles | Nuclear pore complex for nanoparticle entrance into the nucleus | Nuclear target drug delivery | Tkachenko et al. (2003) | |
|
TD (ACSSSPSKHCG) |
Liposome | Targets the Na+/K+-ATPase beta-subunit of the stratum corneum for enhanced skin permeability | Transdermal drug delivery | Zou et al. (2018) |
|
G23 (HLNILSTLWKYRC) |
Polymersome | Targets gangliosides GM1 and GT1b | Blood–brain barrier drug delivery | Georgieva et al. (2012) |
|
LNP (KKRTLRKNDRKKRC) |
DGL-PEG | Cell-penetrating peptide for cellular uptake | Blood–brain barrier drug delivery | Yao et al., (2015) |
|
RGD (ADDADW) |
Fluorescent cyclic peptide nanoparticle | αvβ3 Integrin | Molecular imaging | Fan et al., (2018), Fan et al. (2016) |
|
RGD (RGDFDC) |
Au-tripods | αvβ3 Integrin | Molecular imaging | Cheng et al. (2014) |
|
RGD (CRGDC) |
Poly(ethylene oxide) dendrimer | αvβ3 Integrin | Molecular imaging | Almutairi et al. (2009) |
|
RGD (cRGD) |
Iron oxide nanoparticles | αvβ3 Integrin | Molecular imaging | Xie et al., (2008) |
|
Angiopep-2 (TFFYGGSRGKRNN FKTEEY) |
DTX-loaded PLGA@Au-nanoparticles | Targets glioma | Molecular imaging | Hao et al., (2015) |