REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-β-Actin	Santa Cruz Biotechnology	Cat#sc-47778; RRID:AB_626632
anti-β-Tubulin I	Sigma-Aldrich	Cat#T7816; RRID:AB_261770
anti-Cdk2	Cell Signaling Technology	Cat#2546; RRID:AB_2276129
anti-Cdk4	Cell Signaling Technology	Cat#12790; RRID:AB_2631166
anti-Cdk6	Cell Signaling Technology	Cat#3136; RRID:AB_2229289
anti-CyclinD1	Cell Signaling Technology	Cat#2978; RRID:AB_2259616
anti-CyclinE (HE12)	Santa Cruz Biotechnology	Cat#sc-247; RRID:AB_627357
anti-c-Myc	Cell Signaling Technology	Cat#5605; RRID:AB_1903938
anti-ERα	ThermoFisher Scientific	Cat#MA5-14104; RRID:AB_10975403
anti-RB1	Cell Signaling Technology	Cat#9309; RRID:AB_823629
anti-RB1-pp(S612)	Aviva Systems Biology	Cat#OAAB16108
Chemicals, peptides, and recombinant proteins
phenol red-free improved minimal essential medium	ThermoFisher Scientific	Cat#A10488-01
Faslodex/Fulvestrant; ICI182,780	Selleck Chemicals, Houston, TX	Cat#S1191; CAS#129453-61-8
palbociclib	Selleck Chemicals, Houston, TX	Cat#S1116; CAS#827022-32-2
abemaciclib	Cayman Chemical	Cat#17740; CAS#1231930-82-7
Bovine Calf Serum Charcoal Stripped (CCS)	GeminiBio	Cat#100-213
17β-estradiol (E2)	Sigma-Aldrich, St. Louis, MO	Cat#E8875; CAS#50-28-2
cOmplete Mini Protease Inhibitor Cocktail Tablets	Roche Applied Science	Cat#11836153001
Apotracker	BioLegend, San Diego, CA	Cat#427402
propidium iodide	Thermofisher Scientific Waltham, MA	Cat#P1304MP
Critical commercial assays
Bicinchoninic Acid (BCA) Protein Assay Kit	ThermoFisher Scientific	Cat#23227
SurePrint G3 Human Gene Expression v3 8x60K Microarray Kit	Agilent, Santa Clara, CA	Cat# G4851C; Design ID #072363
Direct-zol RNA Miniprep Kit	Zymo Research, Irvine, CA	Cat#R2052
Deposited data
Microarray data shown in Figure 5	This paper	GEO accession numbers: GSE229002
Experimental models: Cell lines
MCF7	https://doi.org/10.3389/fonc.2021.681530	N/A
Software and algorithms
Code for modeling	This paper	https://doi.org/10.5281/zenodo.7792216
MATLAB 2021	MathWorks, Inc	RRID:SCR_001622; https://www.mathworks.com/products/matlab.html
R	R Core Team, 2013	https://www.r-project.org/
limma (R package)	Ritchie et al., 201591	RRID:SCR_010943; https://bioconductor.org/packages/release/bioc/html/limma.html
clusterProfiler (R package)	Yu et al., 201292 and Wu et al., 202193	RRID:SCR_016884; https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html
msigdbr (R package)	Dolgalev, I. 202194	RRID:SCR_022870; https://cran.r-project.org/package=msigdbr
stats (R package)	R Core Team, 2013	https://www.r-project.org/
tidyverse (R package)	Wickham et al., 201995	RRID:SCR_019186; https://cran.r-project.org/web/packages/tidyverse/index.html
gplots (R package)	Warnes, 201196	https://cran.r-project.org/package=gplots
ggplot2 (R package)	Wickham, 201697	RRID:SCR_014601; https://cran.r-project.org/web/packages/ggplot2/index.html
plotly (R package)	Sievert, 202098	RRID:SCR_013991; https://cran.r-project.org/web/packages/plotly/index.html