Fig. 3.

Dynamic trajectory of cell state transition in sample 2276_10x (A) and sample 2443_10x (B). (C) Dynamic of cell state gene modules along the trajectory of tumor cell type transition. (D) Single-cell analysis of dataset PRJCA001063 showed LY6D+ squamous-like ductal cells were widely observed in PDAC tissues, without detection in adjacent normal tissues. (E) Hypoxia is related to the transition of PDAC cell states include endocrine, exocrine, classical, basal, pEMT, cEMT, and squamous in TCGA-PAAD cohort.