Scheme 1.
Synthesis of hit compound 11 and 12a
aReaction conditions: (a) HCl, H2O, rt; (b) aqueous ammonia, rt; (c) N-(4-(2-bromoacetyl)phenyl)acetamide, EtOH, reflux; (d) H2SO4, EtOH, reflux; (e) acetylchloride, DMF, 0 °C to rt.
Synthesis of hit compound 11 and 12a
aReaction conditions: (a) HCl, H2O, rt; (b) aqueous ammonia, rt; (c) N-(4-(2-bromoacetyl)phenyl)acetamide, EtOH, reflux; (d) H2SO4, EtOH, reflux; (e) acetylchloride, DMF, 0 °C to rt.