Table 1.

The SIRT5 inhibitory activities of analogues 11–13^a.

Cpd.	R	SIRT5 IC50 (μM)	bΔTm (◦C)	ccLogP	dLE
11		26.4 ± 0.8	1.8 ± 0.1	4.04	0.25
12		>400	0.12 ± 0.08	4.64	–
13		200.6 ± 8.9	0.53 ± 0.17	3.97	0.21

^aSuramin was used as a positive control with an IC₅₀ of 28.4 ± 2.5 μM.

^bThe ΔTm values were calculated from the thermal shift assay at a compound concentration of 100 μM.

^ccLogP values were calculated using ChemDraw Ultra 12.0.

^dCalculated LE = 1.4 pIC₅₀ (M)/N, where N is the number of non-hydrogen atom.