Table 2.
Pooled estimates and meta-regression of diagnostic accuracy of typical CT findings
| Number of studies | Sensitivity [95% CI] | p value† | Specificity [95% CI] | p value† | |
|---|---|---|---|---|---|
| Overall | 42 | 0.70 [0.65, 0.74] | 0.90 [0.86, 0.93] | ||
| Meta-regression | |||||
| Prevalence (%)‡ | 0.01 [0.00, 0.02] | 0.0494 | − 0.02 [− 0.04, − 0.01] | 0.0121 | |
| Mean age (years)‡ | 0.01 [− 0.02, 0.04] | 0.4880 | 0.02 [− 0.03, 0.07] | 0.4850 | |
| Proportion of male subjects (%)‡ | − 0.01 [− 0.04, 0.01] | 0.3372 | − 0.03 [− 0.07, 0.01] | 0.1435 | |
| Study size‡ | 0.00 [− 0.03, 0.02] | 0.7879 | 0.02 [− 0.02, 0.06] | 0.4266 | |
| National income | 0.4453 | 0.4219 | |||
| Lower-middle $1086–4255 | 4 | 0.60 [0.43, 0.75] | 0.81 [0.56, 0.94] | ||
| Upper-middle $4256–13,205 | 14 | 0.71 [0.62, 0.78] | 0.90 [0.83, 0.95] | ||
| High > $13,205 | 24 | 0.71 [0.65, 0.77] | 0.91 [0.85, 0.95] | ||
| National income | 0.5707 | 0.4349 | |||
| Developing | 18 | 0.68 [0.61, 0.75] | 0.89 [0.81, 0.93] | ||
| Developed | 24 | 0.71 [0.65, 0.77] | 0.91 [0.87, 0.95] | ||
| Region of the study | 0.2532 | 0.8451 | |||
| Asia & Africa | 8 | 0.65 [0.53, 0.76] | 0.88 [0.75, 0.95] | ||
| Europe | 24 | 0.69 [0.63, 0.74] | 0.91 [0.86, 0.94] | ||
| America | 10 | 0.76 [0.67, 0.83] | 0.91 [0.82, 0.96] | ||
| Full vaccination rate | 0.5943 | 0.0300 | |||
| 0% | 39 | 0.70 [0.65, 0.74] | 0.91 [0.88, 0.94] | ||
| > 0% | 3 | 0.74 [0.56, 0.87] | 0.68 [0.35, 0.89] | ||
| Guide | 0.8268 | 0.7235 | |||
| RSNA | 22 | 0.71 [0.64, 0.77] | 0.91 [0.85, 0.95] | ||
| CO-RADS | 20 | 0.69 [0.63, 0.76] | 0.90 [0.83, 0.94] |
RSNA, Radiological Society of North America; CO-RADS, COVID-19 Reporting and Data System
†Likelihood ratio test between the bivariate models without and with a study-level characteristic
‡For continuous covariates, change in logit (sensitivity or specificity) per 1 unit increase are presented