Table 2.
Statistical analysis of ADHF outcomes according to the ejection fraction at various time points
| Variable | HFrEF (N, %) |
HFmrEF (N, %) |
HFpEF (N, %) |
P-value | |||
|---|---|---|---|---|---|---|---|
| Total | 4832 | 2222 | 5798 | ||||
| Outcomes | |||||||
| 6 months | |||||||
| Primary outcomes | 1314 | (27.2) | 533 | (24.0) | 1202 | (20.7) | < 0.001 |
| All-cause mortality | 727 | (15.1) | 290 | (13.1) | 834 | (14.4) | 0.086 |
| CV death | 370 | (7.7) | 126 | (5.7) | 327 | (5.6) | < 0.001 |
| HF rehospitalization | 1054 | (21.8) | 436 | (19.6) | 962 | (16.6) | < 0.001 |
| AMI | 169 | (3.5) | 87 | (3.9) | 162 | (2.8) | 0.019 |
| Ischemic stroke | 109 | (2.3) | 65 | (2.9) | 207 | (3.6) | < 0.001 |
| 1 year | |||||||
| Primary outcomes | 1679 | (34.8) | 710 | (32.0) | 1632 | (28.2) | < 0.001 |
| All-cause mortality | 1048 | (21.7) | 456 | (20.5) | 1274 | (22.0) | 0.364 |
| CV death | 530 | (11.0) | 198 | (8.9) | 501 | (8.6) | < 0.001 |
| HF rehospitalization | 1348 | (27.9) | 572 | (25.7) | 1297 | (22.4) | < 0.001 |
| AMI | 230 | (4.8) | 126 | (5.7) | 233 | (4.0) | 0.009 |
| Ischemic stroke | 151 | (3.1) | 107 | (4.8) | 283 | (4.9) | < 0.001 |
| 5 years | |||||||
| Primary outcomes | 2560 | (53.0) | 1120 | (50.4) | 2683 | (46.3) | < 0.001 |
| All-cause mortality | 2215 | (45.8) | 1074 | (48.3) | 2938 | (50.7) | < 0.001 |
| CV death | 1052 | (21.8) | 446 | (20.1) | 1090 | (18.8) | < 0.001 |
| HF rehospitalization | 2024 | (41.9) | 879 | (39.6) | 2067 | (35.7) | < 0.001 |
| AMI | 410 | (8.5) | 254 | (11.4) | 441 | (7.6) | < 0.001 |
| Ischemic stroke | 318 | (6.6) | 219 | (9.9) | 606 | (10.5) | < 0.001 |
| Whole period | |||||||
| Primary outcomes | 2813 | (58.2) | 1253 | (56.4) | 2966 | (51.2) | < 0.001 |
| All-cause mortality | 2743 | (56.8) | 1361 | (61.3) | 3700 | (63.8) | < 0.001 |
| CV death | 1292 | (26.7) | 580 | (26.1) | 1386 | (23.9) | < 0.001 |
| HF rehospitalization | 2203 | (45.6) | 972 | (43.7) | 2241 | (38.7) | < 0.001 |
| AMI | 476 | (9.9) | 301 | (13.6) | 541 | (9.3) | < 0.001 |
| Ischemic stroke | 378 | (7.8) | 249 | (11.2) | 693 | (12.0) | < 0.001 |
| Follow years, mean (SD) | 3.8 | (3.6) | 4.1 | (3.6) | 3.8 | (3.6) | 0.002 |