. 2023 May 23;21:345. doi: 10.1186/s12967-023-04200-9

Table 2.

Studies on the treatment of melanoma by affecting the function of mitochondria

Melanoma type	Reagent	Mechanism	References
MAPK mutation	Talimogene laherparepvec(T-VEC)	Oncolytic virus	[36]
	Prenyl-binding protein phosphodiesterase-δ (PDEδ)	NRAS inhibitor	[103]
	Vemurafenib	BRAF inhibitor	[104]
	Dabrafenib	BRAF inhibitor	[105]
	Encorafenib	BRAF inhibitor	[106]
	Sorafenib	BRAF inhibitor	[107]
	Trametinib	MEK inhibitor	[108]
	Cobimetinib	MEK inhibitor	[109]
	Binimetinib	MEK inhibitor	[110]
mtDNA/DNA mutation	Temozolomide (TMZ)	DNA alkylating agent	[111]
	Fotemustine (FM)	DNA alkylating agent	[112, 113]
	Carboplatin/Cisplatin	DNA alkylating agent	[114, 115]
	Dacarbazine (DTIC)	DNA alkylating agent	[116]
	VAS2870	NADPH oxidase inhibitor, Reduce ROS	[117]
	Diphenylene iodonium (DPI)	NADPH oxidase inhibitor, Reduce ROS	[118, 119]
	Irinotecan	Reduce ROS	[120]
	Apocynin (4-Hydroxy-3-methoxyacetophenone)	PI3K inhibitor, Reduce ROS	[121]
Drp1 expression disorder	Vemurafenib	Inhibition of Drp1 phosphorylation	[122]
	Cryptolepine	Drp1 inhibitor	[123]
	mitochondrial division inhibitor-1 (MDIVI-1)	Drp1 inhibitor	[124, 125]
Calcium signal expression disorder	Diallyl trisulfide	Induce mitochondrial Ca²⁺ overload	[126]
	δ-tocotrienol	Induce mitochondrial Ca²⁺ overload	[127]
	Luteolin	Induce tumor cell death	[128]
	N-acetyl-S-(p-chlorophenylcarbamoyl) cysteine (NACC)	Induce tumor cell death	[129]
	Sanguinarine	Induce tumor cell death	[130]
	Aripiprazole	Depletion of endoplasmic reticulum calcium	[131]
	Digitoxin	Alter mitochondrial membrane potential	[132]
	Lmiquimod	Induce Ca²⁺ depletion	[133, 134]
Abnormal tumor mitochondria OXPHOS	Metformin	OXPHOS inhibitor	[135, 136]
	Atovaquone	OXPHOS inhibitor	[135]
	Arsenic trioxide	OXPHOS inhibitor	[135]
	ONC212	OXPHOS inhibitor	[100]
	Mito-MGN	OXPHOS inhibitor	[101]
	MITO-ONC-RX	OXPHOS inhibitor	[137]
	Chitosan biguanide	Mitochondrial function inhibitor	[138, 139]
	Phenformin	Mitochondrial function inhibitor	[140]
	Sorafenib	Mitochondrial function inhibitor, inducing tumor vessel normalization	[141]