Table 2.
Univariate and multivariate analysis
| Factors | Define | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95%CI) | Z(P) | HR (95%CI) | Z(P) | ||
| Age | < 40 | Ref | NA | Ref | NA |
| 40 ~ 60 | 1.346(0.648 ~ 2.795) | 0.796(0.43) | 1.638(0.803 ~ 3.342) | 1.356(0.17) | |
| 60 ~ | 1.653(0.808 ~ 1.106) | 1.375(0.17) | 2.189(1.089 ~ 4.399) | 2.2(0.03) | |
| Marriage | Married | Ref | NA | Ref | NA |
| Divorced | 1.133(1.044 ~ 1.230) | 3.004(< 0.01) | 1.014(0.93 ~ 1.106) | 0.323(0.75) | |
| Single | 1.214(1.130 ~ 1.303) | 5.342(< 0.01) | 1.304(1.201 ~ 1.415) | 6.339(< 0.01) | |
| Other | 1.224(1.119 ~ 1.339) | 4.422(< 0.01) | 1.108(1.006 ~ 1.22) | 2.081(0.04) | |
| Race | White | Ref | NA | Ref | NA |
| Black | 1.174(1.084 ~ 1.270) | 3.958(< 0.01) | 1.162(1.068 ~ 1.264) | 3.492(< 0.01) | |
| Other | 0.978(0.865 ~ 1.106) | -0.355(0.72) | 1.017(0.895 ~ 1.156) | 0.262(0.79) | |
| Sex | Female | Ref | NA | Ref | NA |
| Male | 1.007(0.952 ~ 1.064) | 0.231(0.82) | 1.048(0.985 ~ 1.115) | 1.473(0.14) | |
| Behav | Behav1 | Ref | NA | Ref | NA |
| Behav2 | 0.542(0.486 ~ 0.604) | -11.059(< 0.01) | 0.945(0.841 ~ 1.063) | -0.944(0.35) | |
| Behav3 | 1.028(0.938 ~ 1.127) | 0.599(0.55) | 1.009(0.921 ~ 1.106) | 0.201(0.84) | |
| Behav4 | 0.478(0.407 ~ 0.562) | -8.960(< 0.01) | 0.773(0.652 ~ 0.916) | -2.967(< 0.01) | |
| Other | 1.292(1.168 ~ 1.429) | 4.992(< 0.01) | 1.119(0.995 ~ 1.259) | 1.883(0.06) | |
| Grade | I | Ref | NA | Ref | NA |
| II | 1.678(1.464 ~ 1.922) | 7.456(< 0.01) | 1.094(0.958 ~ 1.249) | 1.32(0.19) | |
| III | 3.228(2.802 ~ 3.792) | 16.221(< 0.01) | 1.338(1.161 ~ 1.542) | 4.026(< 0.01) | |
| IV | 3.459(2.917 ~ 4.102) | 14.267(< 0.01) | 1.283(1.071 ~ 1.537) | 2.702(0.01) | |
| Stage | I | Ref | NA | Ref | NA |
| II | 2.508(2.179 ~ 2.889) | 12.795(< 0.01) | 1.419(1.161 ~ 1.734) | 3.415(< 0.01) | |
| III | 6.391(5.608 ~ 7.282) | 27.831(< 0.01) | 3.68(2.914 ~ 4.648) | 10.942(< 0.01) | |
| IV | 26.820(23.538 ~ 30.560) | 49.387(< 0.01) | 9.704(7.634 ~ 12.335) | 18.566(< 0.01) | |
| Tstage | T1 | Ref | NA | Ref | NA |
| T2 | 1.056(0.875 ~ 1.273) | 0.569((0.57) | 1.14(0.942 ~ 1.378) | 1.345(0.18) | |
| T3 | 3.311(2.841 ~ 3.858) | 15.330(< 0.01) | 1.759(1.445 ~ 2.141) | 5.626(< 0.01) | |
| T4 | 8.809(7.549 ~ 10.278) | 27.639(< 0.01) | 3.029(2.48 ~ 3.7) | 10.866(< 0.01) | |
| Nstage | N0 | Ref | NA | Ref | NA |
| N1 | 3.075(2.854 ~ 3.314) | 29.486(< 0.01) | 0.74(0.58 ~ 0.945) | -2.415(0.02) | |
| N2 | 6.890(6.428 ~ 7.386) | 54.482(< 0.01) | 0.792(0.585 ~ 1.073) | -1.504(0.13) | |
| Surgery | Surg1 | Ref | NA | Ref | NA |
| Surg2 | 0.936(0.866 ~ 1.012) | -1.657(0.098) | 1.047(0.964 ~ 1.136) | 1.090(0.28) | |
| Surg3 | 4.172(3.489 ~ 4.988) | 15.662(< 0.01) | 2.252(1.56 ~ 3.251) | 4.333(< 0.01) | |
| Surg4 | 1.280(1.084 ~ 1.510) | 2.920(0.003) | 0.942(0.789 ~ 1.124) | -0.664(0.51) | |
| LNSur | 4 ~ | Ref | NA | Ref | NA |
| 1 ~ 3 | 1.884(1.637 ~ 2.169) | 8.823(< 0.01) | 0.927(0.705 ~ 1.219) | -0.54(0.59) | |
| None | 1.400(1.164 ~ 1.680) | 3.590(< 0.01) | 1.252(1.021 ~ 1.535) | 2.161(0.03) | |
| SurgOth | None | Ref | NA | Ref | NA |
| Yes | 2.431(2.243 ~ 2.634) | 21.678(< 0.01) | 0.956(0.873 ~ 1.048) | -0.954(0.34) | |
| Radiation | None | Ref | NA | Ref | NA |
| Yes | 2.219(1.890 ~ 2.605) | 9.749(< 0.01) | 1.167(0.968 ~ 1.407) | 1.624(0.10) | |
| Chemotherapy | None | Ref | NA | Ref | NA |
| Yes | 0.455(0.431 ~ 0.482) | -27.591(< 0.01) | 1.554(1.444 ~ 1.672) | 11.774(< 0.01) | |
| Deposits | None | Ref | NA | Ref | NA |
| Yes | 1.586(1.479 ~ 1.702) | 18.878(< 0.01) | 1.179(1.093 ~ 1.272) | 4.253(< 0.01) | |
| LnPositive | No | Ref | NA | Ref | NA |
| 1 ~ 3 | 3.025(2.801 ~ 3.268) | 28.119(< 0.01) | 1.311(1.044 ~ 1.646) | 2.335(0.02) | |
| 4 ~ 6 | 4.451(4.998 ~ 5.945) | 38.318(< 0.01) | 1.714(1.276 ~ 2.3) | 3.584(< 0.01) | |
| > 7 | 8.537(7.909 ~ 9.214) | 55.064(< 0.01) | 2.234(1.681 ~ 2.971) | 5.534(< 0.01) | |
| Bone | None | Ref | NA | Ref | NA |
| Yes | 6.977(5.267 ~ 9.242) | 13.544(< 0.01) | 1.23(0.879 ~ 1.722) | 1.208(0.23) | |
| Brain | None | Ref | NA | Ref | NA |
| Yes | 8.483(5.457 ~ 13.186) | 9.500(< 0.01) | 1.521(0.827 ~ 2.797) | 1.35(0.18) | |
| Liver | None | Ref | NA | Ref | NA |
| Yes | 6.956(6.541 ~ 7.398) | 61.225(< 0.01) | 1.446(1.302 ~ 1.605) | 6.898(< 0.01) | |
| Lung | None | Ref | NA | Ref | NA |
| Yes | 5.844(5.281 ~ 6.468) | 34.124(< 0.01) | 1.206(1.064 ~ 1.367) | 2.924(< 0.01) | |
| Size | < 3 cm | Ref | NA | Ref | NA |
| 3 ~ 5 cm | 1.088(1.001 ~ 1.173) | 2.186(0.03) | 0.979(0.902 ~ 1.062) | -0.514(0.61) | |
| > 5 cm | 1.172(1.096 ~ 1.254) | 4.621(< 0.01) | 0.959(0.893 ~ 1.029) | -1.158(0.25) | |