Table 3.
Genotypic characterization of variants associated with poor gliclazide response
| SNP | Chrom No. | Model | Genotypes | Frequency | Crude OR | p-value* | |
|---|---|---|---|---|---|---|---|
| Cases | Controls | ||||||
| rs2229437 | 11 | DOM | GG and TG vs TT | 77.78 | 36.44 | 6.02 (1.75, 26.73) | 0.002 |
| rs319952 | 1 | REC | AA vs AG and GG | 82.35 | 39.82 | 6.95 (1.80, 39.85) | 0.002 |
| rs393994 | 1 | REC | AA vs AG and GG | 77.78 | 38.98 | 5.41 (1.57, 23.98) | 0.004 |
| rs9806699 | 15 | REC | GG vs AG and AA | 44.44 | 12.71 | 5.39 (1.59, 18.14) | 0.006 |
| rs1234315 | 1 | GENO | TC vs CC | 5.56 | 45.76 | 0.08 (0.001, 0.60) | 0.006 |
| rs7119 | 15 | ALLELIC | TT vs CC | 38.89 | 18.64 | 1.33 (0.37, 4.52) | 0.803 |
| AG vs GG | 55.56 | 44.92 | 2.85 (0.77, 13.21) | 0.138 | |||
| rs6465084 | 7 | REC | AA vs GG | 22.22 | 3.39 | 14.13 (1.92, 114.88) | 0.007 |
Abbrev: ADD, additive; DOM, dominant; DOMDEV, dominant deviant; REC, recessive.
*
Variants are nominally significant at p<0.05