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. Author manuscript; available in PMC: 2023 May 24.
Published in final edited form as: J Neuroimmune Pharmacol. 2021 Nov 10;17(1-2):15–32. doi: 10.1007/s11481-021-10023-6

Fig. 6.

Fig. 6

Oral Treatment with CBD Alleviates Intestinal Inflammation via Inhibition of GSDM Within the Intestinal Tract of EAE Mice. (A) log2 fold change between the mRNA content of IECs isolated from CBD vs VEH treated mice with coding genes significantly upregulated in the IECs of treatment mice (green) and vehicle mice (pink) highlighted (>=2 fold change; p < 0.05). (B) lP-val vs fold change between the mRNA content of IECs isolated from CBD vs VEH treated mice with coding genes significantly upregulated in the IECs of treatment mice (green) and vehicle mice (pink) highlighted (>=2 fold change; p < 0.05). (C) PCA Mapping of the transcriptome of vehicle treated (blue) vs CBD treated (red) IECs (n=2; 5 mice per sample). (D) Heat map of all 390 genes significantly regulated between vehicle and CBD treated groups(>=2 fold change; p < 0.05). (E) Heat map of the 10 significantly regulated genes with the highest and 10 significantly regulated genes with the lowest fold change value between vehicle and treated mice (>=2 fold change; p < 0.05). (F) Representative histology sections of the proximal colon of EAE mice at 4x magnification (left) and 20x magnification (right)