Table 1.
The expression trend of CB1Rs in various neurological diseases.
| Brain Regions | Tendency | Species | Neurological Disorders | References |
|---|---|---|---|---|
| Prefrontal cortex, hippocampus, and caudate putamen |
Decrease | Humans | AD | [53-55] |
| Dorsal hippocampus (DH), basolateral amygdala complex (BLA) | Decrease | Mice(model) | 12-month-old AD | [56] |
| Cerebellum, dentate nucleus | Decrease | Mice(model) | Cerebellar ataxia | [57, 58] |
| Striatum | Decrease | Mice(model) | Huntington's disease | [59, 60] |
| Prefrontal and midcingulate cortex | Decrease | Humans, rat (model) |
Parkinson's disease | [61-63] |