Table 3.

Sample stratification according to brain regions.

N°	Brain Regions	Abs	Brain Portions	n° of NDHC Samples	n° of AD Samples
1	Pre-frontal	PFC	Pre frontal cortex ; dorso-lateral pre frontal cortex; medial prefrontal cortex; ofc (orbitofrontal cortex); orbital prefrontal cortex; ventral forebrain; ventrolateral cortex; ventrolateral prefrontal cortex.	560 (438♂+122♀)	439 (197♂+242♀)
2	Frontal	FC	Frontal cortex frontal pole (Brodmann area 9, 10); medial frontal cortex.	455 (305♂+150♀)	55 (21♂+34♀)
3	Occipital	OC	Occipital cortex; primary visual cortex; visual cortex.	118 (92♂+26♀)	148 (73♂+75♀)
4	Cerebellum	CB	Cerebellar cortex; cerebellum; upper (rostral) rhombic lip.	460 (320♂+140♀)	167 (80♂+87♀)
5	Temporal	TP	Inferior temporal cortex; primary auditory cortex; superior temporal cortex; superior temporal cortex (Brodman area 22); temporal cortex; ventral head of the caudate nucleus.	199 (132♂+67♀)	62 (28♂+34♀)
6	Cingulate	CYN	Anterior cingulate; caudal ganglionic eminence; lateral ganglionic eminence; medial ganglionic eminence; medial temporal gyrus; post central gyrus; posterior cingulate; posterior cingulate cortex; subpial grey matter lesions from the frontal gyri; superior frontal gyrus.	246 (124♂+122♀)	191 (95♂+96♀)
7	Diencephalon	DIE	Basal ganglia; dorsal thalamus; putamen; striatum; nucleus accumbens; substantia nigra; thalamus; mediodorsal nucleus of the thalamus.	111 (77♂+34♀)	52 (11♂+41♀)
8	Limbic System	LS	Amygdala; entorhinal cortex; hippocampus.	286 (172♂+114♀)	167 (55♂+112♀)

Note: All brain samples analyzed were divided into 58 portions, subsequently grouped into the eight main brain regions (pre-frontal, frontal, occipital, cerebellum, temporal, cingulate, diencephalon, and limbic system).

Abbreviations: NDHC = non demented healthy controls subjects; AD = Alzheimer’s Disease patients.