Table 1.
Manifestations associated with Fabry Disease, in order of descending frequency of involvement.
| Organ | Involvement % | Manifestations |
|---|---|---|
| Heart | 68% | Left ventricular hypertrophy |
| - | - | Right ventricular hypertrophy |
| - | - | Congestive heart failure |
| - | - | Arrhythmias |
| - | - | Myocardial ischemia |
| Kidney | 45% | Microalbuminuria |
| - | - | Proteinuria |
| - | - | Progressive renal failure |
| Peripheral Nervous System | 45% | Neuropathic pain |
| - | - | Acroparaesthesias |
| - | - | Acute pain crisis |
| - | - | Thermal sensation deficits |
| - | - | Dysautonomia |
| - | - | Perspiration disorders |
| - | - | Gastrointestinal dysmotility |
| - | - | Median nerve entrapment |
| - | - | Cramp-fasciculation syndrome |
| Eye | 38% | Cornea verticillata |
| - | - | Cataract |
| Central Nervous System |
34% | Ischemic stroke |
| - | - | Transient ischemic attack |
| - | - | Vascular dementia |
| - | - | Hemorrhagic stroke Vertebrobasilar dolichoectasia |
| Skin | 34% | Angiokeratomas |
| - | - | Lymphedema |
| - | - | Coarse facial features |
| Ear | 19% | Hearing loss |
| - | - | Vestibular disturbances |
| Miscellaneous | - | Chronic cough |
| - | - | Osteopenia |
| - | - | Anemia |
| - | - | Azoospermia |
| - | - | Hypothyroidism |