Table 1.
Patient demographic characteristics and comorbidities, stratified by antidepressant.
| - | - | OVERALL | Antidepressant Molecule | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Citalopram | Duloxetine | Escitalopram | Paroxetine | Sertraline | Venlafaxine | Vortioxetine | |||||||||||
| - | N (%) | 8235 | - | 1062 | - | 565 | - | 1939 | - | 1882 | - | 1737 | - | 606 | - | 444 | - |
| Gender | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Female | n (%) | 5535 | 67.2 | 744 | 70.1 | 389 | 68.9 | 1324 | 68.3 | 1285 | 68.3 | 1122 | 64.6 | 395 | 65.2 | 276 | 62.2 |
| Agea | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ≤40 years old | n (%) | 994 | 12.1 | 103 | 9.7 | 46 | 8.1 | 254 | 13.1 | 234 | 12.4 | 204 | 11.7 | 85 | 14.0 | 68 | 15.3 |
| 41-64 years old | n (%) | 3279 | 39.8 | 391 | 36.8 | 249 | 44.1 | 798 | 41.2 | 810 | 43.0 | 588 | 33.9 | 269 | 44.4 | 174 | 39.2 |
| ≥65 years old | n (%) | 3962 | 48.1 | 568 | 53.5 | 270 | 47.8 | 887 | 45.8 | 838 | 44.5 | 945 | 54.4 | 252 | 41.6 | 202 | 45.5 |
| Comorbiditiesb | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Hypertension | n (%) | 3838 | 45.5 | 521 | 44.9 | 274 | 43.6 | 894 | 47.2 | 796 | 46.5 | 872 | 44.7 | 273 | 44.8 | 208 | 43.6 |
| Hyperlipidemia | n (%) | 1804 | 21.4 | 241 | 20.8 | 144 | 22.9 | 400 | 21.1 | 409 | 23.9 | 391 | 20.1 | 122 | 20.0 | 97 | 20.3 |
| Diabetes | n (%) | 1145 | 13.6 | 158 | 13.6 | 92 | 14.6 | 242 | 12.8 | 225 | 13.1 | 274 | 14.1 | 89 | 14.6 | 65 | 13.6 |
| Cerebrovascular Disease | n (%) | 969 | 11.5 | 141 | 12.2 | 77 | 12.2 | 193 | 10.2 | 169 | 9.9 | 240 | 12.3 | 76 | 12.5 | 73 | 15.3 |
| Coronary Artery Disease | n (%) | 674 | 8.0 | 99 | 8.5 | 42 | 6.7 | 164 | 8.7 | 113 | 6.6 | 172 | 8.8 | 50 | 8.2 | 34 | 7.1 |
| Anxiety | n (%) | 876 | 9.1 | 117 | 9.4 | 60 | 9.0 | 200 | 8.9 | 228 | 10.2 | 180 | 8.9 | 55 | 7.7 | 36 | 6.9 |
| Previous history of AD treatment | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Unknownc | n (%) | 1212 | 14.7 | 148 | 13.9 | 72 | 12.7 | 288 | 14.9 | 279 | 14.8 | 247 | 14.2 | 97 | 16.0 | 81 | 18.2 |
| Naive | n (%) | 3209 | 39.0 | 405 | 38.1 | 215 | 38.1 | 771 | 39.8 | 717 | 38.1 | 714 | 41.1 | 205 | 33.8 | 182 | 41.0 |
| Non-naive | n (%) | 3814 | 46.3 | 509 | 47.9 | 278 | 49.2 | 880 | 45.4 | 886 | 47.1 | 776 | 44.7 | 304 | 50.2 | 181 | 40.8 |
a age calculated at index date; b comorbidities 1- year pre index date; c patients without 10 years of available data in IQVIA LPD.