Al‐Salameh 2020.
| Study characteristics | ||
| Notes |
English title The association between body mass index class and coronavirus disease 2019 outcomes Study setting Start of study recruitment (MM/YYYY): NR End of study recruitment (MM/YYYY): 04/2020 Study design: Retrospective cohort Study centre(s): Single centre/clinic/area within a country Number of centres, clinics or areas: 1 Study setting: Inpatient Number of participants recruited: 329 Sampling method: Consecutive participants Participants Female participants (absolute number): 143 Age measure, value: Median (IQR), 72 (61‐84) Inclusion criteria: A confirmed diagnosis of COVID‐19 and inpatient admission to Amiens University Hospital Exclusion criteria: Opposition to data collection by the patient or his/her legal guardian and age under 18 Smoking frequency: 249 Diabetes frequency: 93 Hypertension frequency: 202 Cardiovascular disease frequency: 115 Asthma frequency: NR Chronic obstructive pulmonary disease frequency: 34 Other pulmonary disease frequency: NR Immunosuppression frequency: NR Chronic kidney disease frequency: 50 Cancer frequency: 53 Steroid administration frequency: NR Supplemental oxygen administration frequency: NR Other treatments (frequency): NR Prognostic factor(s) Study’s definition for obesity: Underweight (BMI < 18.5), normal weight (BMI of 18.5‐24.9 kg/m2), overweight (BMI of 25.0‐29.9 kg/m2) and obese (BMI ≥ 30 kg/m2) The time when obesity has been measured: Before disease or right at presentation Main variable used for determination of obesity: BMI Threshold used for definition: 30 Obesity frequency (absolute number): 124 Prognostic factor(s): BMI ≥ 30 kg/m2 Outcome(s) ICU admission Mortality Mechanical ventilation Outcome (prognostic factor) ICU admission (BMI ≥ 30 kg/m2) Follow‐up Number of patients followed completely for the outcome: 329 Number of obese patients followed completely for the outcome: 124 Number of non‐obese patients followed completely for the outcome: 205 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 6 (3.08, 12.52), < 0.0001 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, ALAT > 40 U/I, ASAT > 40 U/I, cancer, cardiac disease, COPD, CRP on admission, CVD total, diabetes, sex (female) Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 3.05 (1.25, 7.82), 0.017 Outcome (prognostic factor) Mortality (BMI ≥ 30 kg/m2) Follow‐up Number of patients followed completely for the outcome: 329 Number of obese patients followed completely for the outcome: 124 Number of non‐obese patients followed completely for the outcome: 205 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 0.78 (0.41, 1.47), 0.44 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, ALAT > 40 U/I, ASAT > 40 U/I, cancer, cardiac disease, COPD, CRP on admission, CVD total, diabetes, sex (female) Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1.35 (0.47, 3.96), 0.025 Outcome (prognostic factor) Mortality (BMI ≥ 30 kg/m2) Follow‐up Number of patients followed completely for the outcome: 329 Number of obese patients followed completely for the outcome: 124 Number of non‐obese patients followed completely for the outcome: 205 Univariable unadjusted analysis for obesity Effect measure for obesity: NR Effect measure value (95% CI), P value: NR Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, sex Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 8.21 (3.21, 25.48), < 0.0001 |
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| Item | Authors' judgement | Support for judgement |
| Study Participation | Yes | Appendix 3 |
| Study Attrition Mortality | Yes | Appendix 3 |
| Study Attrition Mechanical ventilation | Yes | Appendix 3 |
| Study Attrition ICU admission | Yes | Appendix 3 |
| Prognostic Factor Measurement | Yes | Appendix 3 |
| Outcome Measurement Mortality | Yes | Appendix 3 |
| Outcome Measurement Mechanical ventilation | Yes | Appendix 3 |
| Outcome Measurement ICU admission | Yes | Appendix 3 |
| Confounding Bias Mortality | Unclear | Appendix 3 |
| Confounding Bias Mechanical ventilation | No | Appendix 3 |
| Confounding Bias ICU admission | Unclear | Appendix 3 |
| Statistical Analysis Bias | Yes | Appendix 3 |