Bellini 2021.

Study characteristics
Notes	English title Obesity as a risk factor for hospitalization in COronaVIrus Disease19 (COVID‐19) patients: analysis of the Tuscany regional database Study setting Start of study recruitment (MM/YYYY) 30/04/2020 End of study recruitment (MM/YYYY) 30/04/2020 Study design registry data Study centre(s) multiple centres/clinics/areas within a country Number of centres/clinics/areas NR Study setting outpatient and inpatient Number of participants recruited 4481 Sampling method consecutive participants Participants Female participants (percentage), 49.5 Age measure, value NR Inclusion criteria NR Exclusion criteria patients with any missing data Smoking NR Diabetes NR Hypertension NR Cardiovascular diseases NR Please indicate if additional information is available  NR Asthma NR Chronic obstructive pulmonary disease NR Other pulmonary diseases NR Please indicate if additional information is available  NR Immunosuppression NR Please indicate if additional information is available NR Chronic kidney disease NR Cancer NR Steroid administration NR Supplemental oxygen NR Differential values for various oxygenation methods (if indicated) NR Other treatment NR Dose if applicable NR Duration if applicable NR Percentage received this treatment NR Prognostic factor(s) Study’s definition for obesity Obesity was defined as BMI ≥ 30 kg/m2 The time when obesity has been measured before disease or right at presentation Main variable used for determination of obesity BMI Threshold used for definition of obesity  BMI ≥ 30 kg/m2 Measure of frequency absolute number Frequency value 157 How many eligible outcomes reported? 1 How many eligible outcomes reported? 1 Outcome(s) hospitalisation Outcome (prognostic factor) Hospitalisation (BMI > 30 kg/m2 (obese)) Outcome Hospitalisation Prognostic factor (category):  BMI > 30 kg/m2 (obese) Follow‐up Number of patients followed completely for this outcome  4481 Number of obese patients followed completely for this outcome  157 Number of non‐obese patients followed completely for this outcome  4424 Univariable (unadjusted) analysis for obesity Effect measure for obesity relative risk Effect measure value (95% CI) 1.74 (1.56, 1.97) Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment Age, sex, all factors associated with hospitalisation at univariate analysis as possible confounders (factors were not reported) Effect measure for obesity odds ratio  Effect measure value (95% CI) 3 (2.16, 4.29) Outcome (prognostic factor) Hospitalisation (BMI > 30 kg/m2 (obese)) Outcome Hospitalisation Prognostic factor (category):  BMI > 30 kg/m2 (obese) Follow‐up Number of patients followed completely for this outcome  2307 Number of obese patients followed completely for this outcome  NR Number of non‐obese patients followed completely for this outcome  NR Univariable (unadjusted) analysis for obesity Effect measure for obesity NR Effect measure value (95% CI) NR Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment Age, sex, all factors associated with hospitalisation at univariate analysis as possible confounders (factors were not reported) Effect measure for obesity odds ratio  Effect measure value (95% CI) 4.08 (2.53, 6.77) Outcome (prognostic factor) Hospitalisation (BMI > 30 kg/m2 (obese)) Outcome Hospitalisation Prognostic factor (category):  BMI > 30 kg/m2 (obese) Follow‐up Number of patients followed completely for this outcome  2377 Number of obese patients followed completely for this outcome  NR Number of non‐obese patients followed completely for this outcome  NR Univariable (unadjusted) analysis for obesity Effect measure for obesity NR Effect measure value (95% CI) NR Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment Age, sex, all factors associated with hospitalisation at univariate analysis as possible confounders (factors were not reported) Effect measure for obesity odds ratio  Effect measure value (95% CI) 1.91 (1.4, 2.65)
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition Hospitalisation	Yes	Appendix 3
Prognostic Factor Measurement	Unclear	Appendix 3
Outcome Measurement Hospitalisation	Yes	Appendix 3
Confounding Bias Hospitalisation	Yes	Appendix 3
Statistical Analysis Bias	Unclear	Appendix 3