Calmes 2021.

Study characteristics
Notes	English title Asthma and COPD are not risk factors for ICU stay and death in case of SARS‐CoV2 infection Study setting Start of study recruitment (MM/YYYY): 03/2020 End of study recruitment (MM/YYYY): 04/2020 Study design: Registry data Study centre(s): Single centre/clinic/area within a country Number of centres, clinics or areas: 1 Study setting: Inpatient Number of participants recruited: 596 Sampling method: Consecutive participants Participants Female participants (absolute number): 302 Age measure, value: NR Inclusion criteria: adult patients who were hospitalised in University Hospital of Liege between March 18 and April 17, 2020, for COVID‐19 Exclusion criteria: NR Smoking frequency: 50 Diabetes frequency: 124 Hypertension frequency: 246 Cardiovascular disease frequency: 116 Asthma frequency: 57 Chronic obstructive pulmonary disease frequency: 46 Other pulmonary disease frequency: emphysema (70), bronchiectasis (23) Immunosuppression frequency: 32 Chronic kidney disease frequency: 42 Cancer frequency: 70 Steroid administration frequency: inhaled corticosteroid (56), oral corticosteroid (23) Supplemental oxygen administration frequency: 41 Other treatments (frequency): hydroxychloroquine (596), doxycycline (596) Prognostic factor(s) Study’s definition for obesity: NR The time when obesity has been measured: NR Main variable used for determination of obesity: BMI Threshold used for definition: NR Obesity frequency (absolute number): 115 Prognostic factor(s): Obesity Outcome(s) ICU admission Death Outcome (prognostic factor) ICU admission (obesity) Follow‐up Number of patients followed completely for the outcome: 595 Number of obese patients followed completely for the outcome: NR Number of non‐obese patients followed completely for the outcome: NR Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 9 (4.5, 15), < 0.0001 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, sex Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 8.5 (5.10, 14), < 0.0001 Outcome (prognostic factor) Death (obesity) Follow‐up Number of patients followed completely for the outcome: 595 Number of obese patients followed completely for the outcome: NR Number of non‐obese patients followed completely for the outcome: NR Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 2 (1.2, 3.3), 0.0078 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Male gender, older age Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1.80 (1.10, 3.20), 0.029
Item	Authors' judgement	Support for judgement
Study Participation	Unclear	Appendix 3
Study Attrition Mortality	No	Appendix 3
Study Attrition ICU admission	No	Appendix 3
Prognostic Factor Measurement	No	Appendix 3
Outcome Measurement Mortality	Yes	Appendix 3
Outcome Measurement ICU admission	Yes	Appendix 3
Confounding Bias Mortality	Yes	Appendix 3
Confounding Bias ICU admission	Yes	Appendix 3
Statistical Analysis Bias	Yes	Appendix 3