Mehta 2021b.

Study characteristics
Notes	English title Epicardial adipose tissue thickness is associated with increased severity and mortality related to SARS‐CoV‐2 infection Study setting Start of study recruitment (MM/YYYY) 03/2020 End of study recruitment (MM/YYYY) 05/2020 Study design NR Study centre(s) single centres/clinics/areas within a country Number of centres/clinics/areas NR Study setting NR Number of participants recruited 748 Sampling method consecutive participants Participants Female participants (absolute number), 278 Age measure, value mean (standard deviation), 51.22 (13.62) Inclusion criteria This study included consecutive patients evaluated at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), a COVID‐19 reference centre in Mexico City between 17th March and 31st May 2020. Exclusion criteria NR Smoking NR Diabetes (absolute number), 191 Hypertension (absolute number), 212 Cardiovascular diseases (proportion), 19 Please indicate if additional information is available  NR Asthma NRNR Chronic obstructive pulmonary disease NR Other pulmonary diseases NR Please indicate if additional information is available  NR Immunosuppression NR Please indicate if additional information is available NR Chronic kidney disease (absolute number), 26 Cancer NR Steroid administration NR Supplemental oxygen (absolute number), 138 Differential values for various oxygenation methods (if indicated) intubation Other treatment NR Dose if applicable NR Duration if applicable NR Percentage received this treatment NR Prognostic factor(s) Study’s definition for obesity NR The time when obesity has been measured unspecified Main variable used for determination of obesity BMI Threshold used for definition of obesity  unspecified Measure of frequency absolute number Frequency value 300 How many eligible outcomes reported? 2 How many eligible outcomes reported? 2 Outcome(s) mortality, mechanical ventilation Outcome (prognostic factor) Mortality (obesity) Outcome Mortality Prognostic factor (category):  Obesity Follow‐up Number of patients followed completely for this outcome  748 Number of obese patients followed completely for this outcome  300 Number of non‐obese patients followed completely for this outcome  448 Univariable (unadjusted) analysis for obesity Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.091 (0.93, 1.28) Multivariable (adjusted) analysis for obesity Modelling method Cox regression The set of prognostic factors used for adjustment age, gender and comorbid conditions Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.262 (1.042, 1.529) Outcome (prognostic factor) invasive ventilation (obesity) Outcome invasive ventilation Prognostic factor (category):  Obesity Follow‐up Number of patients followed completely for this outcome  748 Number of obese patients followed completely for this outcome  300 Number of non‐obese patients followed completely for this outcome  448 Univariable (unadjusted) analysis for obesity Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.408 (1.167, 1.705) Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment age, gender and comorbid conditions Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.418 (1.149, 1.766) Outcome (prognostic factor) Mortality (visceral obesity (based on epicardial adipose tissue)) Outcome Mortality Prognostic factor (category):  visceral obesity (based on epicardial adipose tissue) Follow‐up Number of patients followed completely for this outcome  748 Number of obese patients followed completely for this outcome  150 Number of non‐obese patients followed completely for this outcome  598 Univariable (unadjusted) analysis for obesity Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.57 (1.123, 2.196) Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment age, gender and comorbid conditions, BMI Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.409 (1.006, 1.975) Outcome (prognostic factor) invasive ventilation (visceral obesity (based on epicardial adipose tissue)) Outcome invasive ventilation Prognostic factor (category):  visceral obesity (based on epicardial adipose tissue) Follow‐up Number of patients followed completely for this outcome  748 Number of obese patients followed completely for this outcome  150 Number of non‐obese patients followed completely for this outcome  598 Univariable (unadjusted) analysis for obesity Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.69 (1.094, 2.572) Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment age, gender and comorbid conditions, BMI Effect measure for obesity hazard ratio Effect measure value (95% CI) 1.689 (1.078, 2.614)
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition Mortality	Yes	Appendix 3
Study Attrition Mechanical ventilation	Yes	Appendix 3
Prognostic Factor Measurement	No	Appendix 3
Outcome Measurement Mortality	Yes	Appendix 3
Outcome Measurement Mechanical ventilation	Unclear	Appendix 3
Confounding Bias Mortality	Yes	Appendix 3
Confounding Bias Mechanical ventilation	Yes	Appendix 3
Statistical Analysis Bias	Yes	Appendix 3