Motaib 2021.

Study characteristics
Notes	English title Obesity and disease severity among patients with COVID‐19 Study setting Start of study recruitment (MM/YYYY) 03/2020 End of study recruitment (MM/YYYY) 05/2020 Study design retrospective cohort Study centre(s) single centres/clinics/areas within a country Number of centres/clinics/areas 1 Study setting inpatient Number of participants recruited 107 Sampling method consecutive participants Participants Female participants (absolute number), 43 Age measure, value median (interquartile range), 53 (36, 64) Inclusion criteria We included all adult patients with laboratory‐confirmed SARS‐CoV‐2 infection, using a reverse transcriptase‐polymerase chain reaction assay, who were admitted to Sheikh Khalifa Ibn Zaid International University Hospital between March 20 and May 10, 2020. Exclusion criteria We excluded from our study pregnant women and those patients under the age of 18. Smoking NR Diabetes (absolute number), 16 Hypertension (absolute number), 33 Cardiovascular diseases (absolute number), 16 Please indicate if additional information is available  NR Asthma NR Chronic obstructive pulmonary disease NR Other pulmonary diseases (absolute number), 9 Please indicate if additional information is available  in terms of respiratory disease Immunosuppression NR Please indicate if additional information is available NR Chronic kidney disease NR Cancer NR Steroid administration NR Supplemental oxygen (absolute number), 13 Differential values for various oxygenation methods (if indicated) in terms of invasive mechanical ventilation Other treatment NR Dose if applicable NR Duration if applicable NR Percentage received this treatment NR Prognostic factor(s) Study’s definition for obesity According to the WHO classification, obesity was defined as having a body mass index (BMI) greater than or equal to 30 kg/m² (BMI ≥ 30 kg/m²) The time when obesity has been measured unspecified Main variable used for determination of obesity BMI Threshold used for definition of obesity  NR Measure of frequency absolute number Frequency value 24 How many eligible outcomes reported? 1 How many eligible outcomes reported? 1 Outcome(s) ICU admission Outcome (prognostic factor) ICU admission (BMI ≥ 30) Outcome ICU admission Prognostic factor (category):  BMI ≥ 30 Follow‐up Number of patients followed completely for this outcome  107 Number of obese patients followed completely for this outcome  24 Number of non‐obese patients followed completely for this outcome  83 Univariable (unadjusted) analysis for obesity Effect measure for obesity odds ratio  Effect measure value (95% CI) 2.75 (1.08, 6.97) Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment Age, sex, obesity, HTN, DM, CVD, other diseases, respiratory symptoms Effect measure for obesity odds ratio  Effect measure value (95% CI) 5.24 (1.05, 26.2) Outcome (prognostic factor) ICU admission (BMI ≥ 30) Outcome ICU admission Prognostic factor (category):  BMI ≥ 30 Follow‐up Number of patients followed completely for this outcome  107 Number of obese patients followed completely for this outcome  24 Number of non‐obese patients followed completely for this outcome  83 Univariable (unadjusted) analysis for obesity Effect measure for obesity odds ratio  Effect measure value (95% CI) 3.12 (1.1, 8.86) Multivariable (adjusted) analysis for obesity Modelling method logistic regression The set of prognostic factors used for adjustment Age, sex, obesity, HTN, DM, CVD, respiratory, dyslipidaemia, other diseases, clinical symptoms Effect measure for obesity odds ratio  Effect measure value (95% CI) 9.55 (1.36, 67.29)
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition ICU admission	Yes	Appendix 3
Prognostic Factor Measurement	Yes	Appendix 3
Outcome Measurement ICU admission	Yes	Appendix 3
Confounding Bias ICU admission	Yes	Appendix 3
Statistical Analysis Bias	Yes	Appendix 3